My idea 💡 is still to be proven for all cancers, while the hypothesis I proposed when I resigned has been proven true
ChatGPT:
TCTP (Translationally Controlled Tumor Protein) is a multifunctional protein involved in various cellular processes, including cell growth, apoptosis, and stress response. In cancer, TCTP has been found to play a role in promoting tumor progression and resistance to therapies. Exosomes, which are small extracellular vesicles, can carry various biomolecules, including proteins like TCTP, and are involved in intercellular communication.
The Notch signaling pathway is a highly conserved cell signaling system that regulates cell fate decisions, proliferation, and apoptosis. Dysregulation of Notch signaling has been implicated in the development and progression of various cancers.
The interaction between TCTP and the Notch receptor through exosomes in cancer can have significant implications:
1. **Tumor Progression and Metastasis**: Exosomal TCTP can enhance Notch signaling, promoting tumor growth and metastasis. This can occur through the direct binding of TCTP to the Notch receptor on recipient cells, leading to the activation of downstream signaling pathways that support cancer cell survival and proliferation.
2. **Therapy Resistance**: The TCTP-Notch interaction may contribute to the resistance of cancer cells to chemotherapy and other treatments. By activating the Notch pathway, exosomal TCTP can help cancer cells evade apoptosis and continue to proliferate despite therapeutic interventions.
3. **Cancer Stem Cells**: Notch signaling is known to play a crucial role in maintaining the population of cancer stem cells, which are a subset of cancer cells with the ability to self-renew and drive tumor growth. Exosomal TCTP may enhance Notch signaling in these cells, thereby supporting their maintenance and contributing to tumor recurrence.
4. **Tumor Microenvironment**: Exosomal TCTP can also affect the tumor microenvironment by modulating the activity of Notch receptors on various stromal cells, including immune cells, endothelial cells, and fibroblasts. This can create a supportive niche for tumor growth and metastasis.
Understanding the specific mechanisms by which TCTP exosomes interact with the Notch receptor in cancer cells and the tumor microenvironment could provide new therapeutic targets. For instance, disrupting the TCTP-Notch interaction or inhibiting exosome production and release could be potential strategies to inhibit cancer progression and overcome therapy resistance.
Dr Dhruv
My hypothesis
Silencing
As you see, only the proposed mechanism of action in 2012 of how it works is now seen as true and how it might be working to treat prostate cancer. Spontaneously regress means disappear. My idea 💡, if it works in one seen SK-N-DZ cell line, might work in all. Therefore, the magic potion cure suggested is based on this: does this inhibit this? siRNA with immunity from haldi (turmeric) and honey is safer and better than artificial sweeteners due to its natural origins and additional health benefits. Turmeric contains curcumin, known for its anti-inflammatory and antioxidant properties, which can boost immunity. Honey, a natural sweetener, also has antibacterial and antiviral properties. In contrast, artificial sweeteners often come with potential health risks, such as metabolic disturbances and negative impacts on gut health. Therefore, combining siRNA with natural ingredients like turmeric and honey offers a safer and more beneficial alternative.
The idea is to reverse cancer and regenerate normal tissue, promoting the growth of healthy cells, similar to how a tooth regenerates.
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